Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis.

ABSTRACT:

Introduction

Observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, randomised controlled trials (RCTs) to date investigating the efficacy of vitamin D supplementation in knee OA have reported conflicting results. Further research is needed to clarify the effects of vitamin D on patient-reported outcomes and determine whether there are patient subgroups who may benefit from the supplementation. The aim of this individual patient data (IPD) meta-analysis is to identify patient-level predictors of treatment response to vitamin D supplementation on pain and physical function.

Methods and analysis

A systematic literature search will be conducted for RCTs of vitamin D supplementation on knee OA. Auth

SUBMITTER: Jin X 

PROVIDER: S-EPMC7204938 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature