Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy.

ABSTRACT: Changes in maternal immunity during pregnancy can result in an altered immune state, and as a natural perturbation, this provides an opportunity to understand functional interactions of the immune system in vivo. We report characterization of maternal peripheral immune phenotypes for 33 longitudinally sampled normal pregnancies, using clinical measurements of complete blood counts and major immune cell populations, as well as high parameter flow cytometry for 30 leukocyte antigens characterizing 79 cell populations, and monitoring of 1305 serum proteins using the SomaLogic platform. Cellular analyses characterized transient changes in T cell polarization and more persistent alterations in T and B cell subset frequencies and activation. Serum proteomic analysis identified a potentially nove

SUBMITTER: Apps R 

PROVIDER: S-EPMC7205264 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature