Mid-trimester amniotic fluid proteome's association with spontaneous preterm delivery and gestational duration.

ABSTRACT:

Background

Amniotic fluid is clinically accessible via amniocentesis and its protein composition may correspond to birth timing. Early changes in the amniotic fluid proteome could therefore be associated with the subsequent development of spontaneous preterm delivery.

Objective

The main objective of this study was to perform unbiased proteomics analysis of the association between mid-trimester amniotic fluid proteome and spontaneous preterm delivery and gestational duration, respectively. A secondary objective was to validate and replicate the findings by enzyme-linked immunosorbent assay using a second independent cohort.

Methods

Women undergoing a mid-trimester genetic amniocentesis at Sahlgrenska University Hospital/Östra between September 2008 and September 2011 w

SUBMITTER: Hallingstrom M 

PROVIDER: S-EPMC7205297 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature