Ontology highlight
ABSTRACT:
SUBMITTER: Ide S
PROVIDER: S-EPMC7205460 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Ide Shintaro S Yahara Yasuhito Y Kobayashi Yoshihiko Y Strausser Sarah A SA Ide Kana K Watwe Anisha A Xu-Vanpala Shengjie S Privratsky Jamie R JR Crowley Steven D SD Shinohara Mari L ML Alman Benjamin A BA Souma Tomokazu T
eLife 20200417
Renal macrophages represent a highly heterogeneous and specialized population of myeloid cells with mixed developmental origins from the yolk-sac and hematopoietic stem cells (HSC). They promote both injury and repair by regulating inflammation, angiogenesis, and tissue remodeling. Recent reports highlight differential roles for ontogenically distinct renal macrophage populations in disease. However, little is known about how these populations change over time in normal, uninjured kidneys. Prior ...[more]