The effect of interleukin 10 polymorphisms on breast cancer susceptibility in Han women in Shaanxi Province.

ABSTRACT:

Background

Previous studies have reported on several genetic variants related to breast cancer, but a substantial proportion of mutation loci have not yet been identified. In the current study, we aimed to evaluate the association between single nucleotide polymorphisms (SNPs) of interleukin-10 (IL-10) and susceptibility to breast cancer in Shaanxi Han women in China.

Methods

Six SNPs were genotyped in 530 breast cancer patients and 628 healthy women from the First Affiliated Hospital of Xi'an Jiaotong University Hospital. Odds ratios and 95% confidence intervals were calculated by unconditional logistic regression analysis to assess the association between breast cancer risk and polymorphisms of six loci.

Results

Two SNPs, rs3024490 and rs1800871, were found to be si

SUBMITTER: Li M 

PROVIDER: S-EPMC7205473 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature