Fear conditioning and extinction in alcohol dependence: Evidence for abnormal amygdala reactivity.

ABSTRACT: Fear conditioning and extinction (FCE) are vital processes in adaptive emotion regulation and disrupted in anxiety disorders. Despite substantial comorbidity between alcohol dependence (ALC) and anxiety disorders and reports of altered negative emotion processing in ALC, neural correlates of FCE in this clinical population remain unknown. Here, we used a 2-day fear learning paradigm in 43 healthy participants and 43 individuals with ALC at the National Institutes of Health. Main outcomes of this multimodal study included structural and functional brain magnetic resonance imaging, clinical measures, as well as skin conductance responses (SCRs) to confirm differential conditioning. Successful FCE was demonstrated across participants by differential SCRs in the conditioning phase and no diffe

SUBMITTER: Muench C 

PROVIDER: S-EPMC7205585 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature