Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice.

ABSTRACT: Modulation of the ageing process by dietary restriction (DR) across multiple taxa is well established. While the exact mechanism through which DR acts remains elusive, the gasotransmitter hydrogen sulphide (H₂S) may play an important role. We employed a comparative-type approach using females from three ILSXISS recombinant inbred mouse strains previously reported to show differential lifespan responses following 40% DR. Following long-term (10 months) 40% DR, strain TejJ89-reported to show lifespan extension under DR-exhibited elevated hepatic H₂S production relative to its strain-specific ad libitum (AL) control. Strain TejJ48 (no reported lifespan effect following 40% DR) exhibited significantly reduced hepatic H₂S production, while H₂S product

SUBMITTER: Wilkie SE 

PROVIDER: S-EPMC7205779 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature