Acid-sensing ion channel 3 blockade inhibits durovascular and nitric oxide-mediated trigeminal pain.

ABSTRACT:

Background and purpose

There is a major unmet need to develop new therapies for migraine. We have previously demonstrated the therapeutic potential of the acid-sensing ion channel (ASIC) blockade in migraine, via an ASIC1 mechanism. ASIC3 is expressed in the trigeminal ganglion and its response is potentiated by NO that can trigger migraine attacks in patients. Thus we sought to explore the potential therapeutic effect of ASIC3 blockade in migraine.

Experimental approach

To investigate this, we utilised validated electrophysiological and behavioural rodent preclinical models. In rats, ASIC3 blockade using APETx2 (50 or 100 μg·kg^-1 , i.v.) was measured by using durovascular and NO-evoked trigeminal nociceptive responses along with cortical spreading depression mode

SUBMITTER: Holton CM 

PROVIDER: S-EPMC7205795 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature