Intestinal fatty acid-binding protein mediates atherosclerotic progress through increasing intestinal inflammation and permeability.

ABSTRACT: Atherosclerosis is one of leading phenotypes of cardiovascular diseases, featured with increased vascular intima-media thickness (IMT) and unstable plaques. The interaction between gastrointestinal system and cardiovascular homeostasis is emerging as a hot topic. Therefore, the present study aimed to explore the role of an intestinal protein, intestinal fatty acid-binding protein (I-FABP/FABP2) in the atherosclerotic progress. In western diet-fed ApoE^-/- mice, FABP2 was highly expressed in intestine. Silence of intestinal Fabp2 attenuated western diet-induced atherosclerotic phenotypes, including decreasing toxic lipid accumulation, vascular fibrosis and inflammatory response. Mechanistically, intestinal Fabp2 knockdown improved intestinal permeability through increasing the exp

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7205806 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature