Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis.

ABSTRACT: There are unresolved questions regarding the association between persistent leukocytosis and risk of thrombosis and disease evolution in polycythemia vera (PV), as much of the published literature on the topic does not appropriately use repeated-measures data or time-dependent modeling to answer these questions. To address this knowledge gap, we analyzed a retrospective database of 520 PV patients seen at 10 academic institutions across the United States. Taking hematologic laboratory data at ∼3-month intervals (or as available) for all patients for duration of follow-up, we used group-based trajectory modeling to identify latent clusters of patients who follow distinct trajectories with regard to their leukocyte, hematocrit, and platelet counts over time. We then tested the association be

SUBMITTER: Ronner L 

PROVIDER: S-EPMC7205813 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature