RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer.

ABSTRACT: Disabled tumor suppressor genes and hyperactive oncogenes greatly contribute to cell fates during cancer development because of their genetic alterations such as somatic mutations. However, little is known about how tumor suppressor genes react to diverse oncogenes during tumor progression. Our previous study showed that RUNX3 inhibits invasiveness by preventing vascular endothelial growth factor secretion and suppressed endothelial cell growth and tube formation in colorectal cancer (CRC). Hedgehog signaling is crucial for the physiological maintenance and self-renewal of stem cells, and its deregulation is responsible for their tumor development. The mechanisms that inhibit this pathway during proliferation remain poorly understood. Here, we found that the tumor suppressor RUNX3 modulate

SUBMITTER: Kim BR 

PROVIDER: S-EPMC7205901 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature