Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans.

ABSTRACT: The C. elegans germline recapitulates mammalian stem cell niches and provides an effective platform for investigating key aspects of stem cell biology. However, the molecular and physiological requirements for germline stem cell homeostasis remain largely elusive. Here, we report that mitochondrial biogenesis and function are crucial for germline stem cell identity. We show that general transcription activity in germline mitochondria is highly compartmentalized, and determines mitochondrial maturation. RPOM-1, the mitochondrial RNA polymerase, is differentially expressed as germ nuclei progress from the distal to the proximal gonad arm to form oocytes. Mitochondria undergo changes from globular to tubular morphology and become polarized, as they approach the proximal gonad arm. Notably, th

SUBMITTER: Charmpilas N 

PROVIDER: S-EPMC7206027 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature