The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors.

ABSTRACT: Autophagy is an intracellular lysosomal degradative pathway important for tumor surveillance. Autophagy deficiency can lead to tumorigenesis. Autophagy is also known to be important for the aggressive growth of tumors, yet the mechanism that sustains the growth of autophagy-deficient tumors is not unclear. We previously reported that progression of hepatic tumors developed in autophagy-deficient livers required high mobility group box 1 (HMGB1), which was released from autophagy-deficient hepatocytes. In this study we examined the pathological features of the hepatic tumors and the mechanism of HMGB1-mediated tumorigenesis. We found that in liver-specific autophagy-deficient (Atg7^ΔHep) mice the tumors cells were still deficient in autophagy and could also release HMGB1. Histolog

SUBMITTER: Khambu B 

PROVIDER: S-EPMC7206028 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature