ATF3 promotes erastin-induced ferroptosis by suppressing system Xc^.

ABSTRACT: The amino acid antiporter system Xc^- is important for the synthesis of glutathione (GSH) that functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent death (i.e., ferroptosis). While the activity of system Xc^- often positively correlates with the expression level of its light chain encoded by SLC7A11, inhibition of system Xc^- activity by small molecules (e.g., erastin) causes a decrease in the intracellular GSH level, leading to ferroptotic cell death. How system Xc^- is regulated during ferroptosis remains largely unknown. Here we report that activating transcription factor 3 (ATF3), a common stress sensor, can promote ferroptosis induced by erastin. ATF3 suppressed system Xc^-, depleted intracellular

SUBMITTER: Wang L 

PROVIDER: S-EPMC7206049 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature