Two well-differentiated pancreatic neuroendocrine tumor mouse models.

ABSTRACT: Multiple endocrine neoplasia type 1 (MEN1) is a genetic syndrome in which patients develop neuroendocrine tumors (NETs), including pancreatic neuroendocrine tumors (PanNETs). The prolonged latency of tumor development in MEN1 patients suggests a likelihood that other mutations cooperate with Men1 to induce PanNETs. We propose that Pten loss combined with Men1 loss accelerates tumorigenesis. To test this, we developed two genetically engineered mouse models (GEMMs)-MPR (Men1^flox/flox Pten^flox/flox RIP-Cre) and MPM (Men1^flox/flox Pten^flox/flox MIP-Cre) using the Cre-LoxP system with insulin-specific biallelic inactivation of Men1 and Pten. Cre in the MPR mouse model was driven by the transgenic rat insulin 2 promoter while in the MPM mouse model wa

SUBMITTER: Wong C 

PROVIDER: S-EPMC7206057 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature