An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons.

ABSTRACT: During high-frequency network activities, fast-spiking, parvalbumin-expressing basket cells (PV⁺-BCs) generate barrages of fast synaptic inhibition to control the probability and precise timing of action potential (AP) initiation in principal neurons. Here we describe a subcellular specialization that contributes to the high speed of synaptic inhibition mediated by PV⁺-BCs. Mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel distribution in rat hippocampal PV⁺-BCs with subcellular patch-clamp methods revealed that functional HCN channels are exclusively expressed in axons and completely absent from somata and dendrites. HCN channels not only enhance AP initiation during sustained high-frequency firing but also speed up the propagati

SUBMITTER: Roth FC 

PROVIDER: S-EPMC7206118 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature