Risk factors for the development of cutaneous melanoma after allogeneic hematopoietic cell transplantation.

ABSTRACT:

Background

Melanoma risk is increased after allogeneic hematopoietic cell transplantation (HCT), but specific risk factors are unknown.

Objective

Investigate risk factors for melanoma after allogeneic hematopoietic cell transplantation.

Methods

We conducted a nested case-control study of 140 melanoma cases and 557 controls (matched by age at HCT, sex, primary disease, survival time) through the Center for International Blood and Marrow Transplant Research.

Results

Melanoma risk was significantly increased among HCT survivors who received total body irradiation-based myeloablative conditioning (multivariable adjusted odds ratio [OR] = 1.77; 95% confidence interval [CI] = 1.00-3.15) or reduced-intensity conditioning containing melphalan (OR = 2.60; 95% CI = 1.13-

SUBMITTER: Herr MM 

PROVIDER: S-EPMC7206613 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature