Identification of a m⁶A RNA methylation regulators-based signature for predicting the prognosis of clear cell renal carcinoma.

ABSTRACT:

Background

The mortality rate of clear cell renal cell carcinoma (ccRCC) remains high. The aim of this study was to identify novel prognostic biomarkers by using m⁶A RNA methylation regulators capable of improving the risk-stratification criteria of survival for ccRCC patients.

Methods

The gene expression data of 16 m⁶A methylation regulators and its relevant clinical information were extracted from The Cancer Genome Atlas (TCGA) database. The expression pattern of these m⁶A methylation regulators were evaluated. Consensus clustering analysis was conducted to identify clusters of ccRCC patients with different prognosis. Univariate, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analysis were performed

SUBMITTER: Chen J 

PROVIDER: S-EPMC7206820 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature