Effects of coal-fired PM_2.5 on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE^-/- mice.

ABSTRACT:

Background

Air pollution increases the morbidity and mortality of cardiovascular disease (CVD). Atherosclerosis (AS) is the pathological basis of most CVD, and the progression of atherosclerosis and the increase of fragile plaque rupture are the mechanism basis of the relationship between atmospheric particulate pollution and CVD. The aim of the present study was to investigate the effects of coal-fired fine particulate matter (PM_2.5) on the expression levels of atherosclerosis-related proteins (von Willebrand factor (vWF), Endothelin-1 (ET-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin, and to explore the role and mechanism of the progression of atherosclerosis induced by coal-fired PM_2.5 via the mitogen-activated protein kinase (MAPK) signali

SUBMITTER: Wang S 

PROVIDER: S-EPMC7206822 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature