Heterochromatin drives compartmentalization of inverted and conventional nuclei.

ABSTRACT: The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome^1,2. In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery^1,2. Genome-wide chromosome conformation capture (Hi-C) analyses show this segregation as a plaid pattern of contact enrichment within euchromatin and heterochromatin compartments³, and depletion between them. Many mechanisms for the formation of compartments have been proposed, such as attraction of heterochromatin to the nuclear lamina^2,4, preferential attraction of similar chromatin to each other^1,4-12, higher levels of chromatin mobility in active ch

SUBMITTER: Falk M 

PROVIDER: S-EPMC7206897 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature