Project description:We isolated PBMC from healthy, moderate ( Oxygen supply < 10L/min), and severe (Oxygen supply >= 10L/min) COVID-19 patients after their admission to Intensive Care Units (ICU), at two timepoints (Day-1 and Day-4); and performed both CD14+ Monocyte enrichment followed by a Pan-DC kit to retrieve all Antigen Presenting Cell (APC) subsets from these age-matched patients. We performed single cell RNA sequencing using 10X technology on the single cell suspensions and constracted a high-resolution map of 81,643 Antigen Presenting Cells (APC) from the three COVID-19 severity groups. We were able to retrieve all the known six APC subsets and deciphered the altered pathways and ati-viral mechanisms, correlated with the disease severity.

2021-05-10 | GSE169346 | GEO

Signatures of cardioembolic and large-vessel ischemic stroke.

Project description: Not available

| S-EPMC2967466 | biostudies-literature

COVID-19-associated Large Vessel Stroke in a 28-year-old Patient : NETs and Platelets Possible Key Players in Acute Thrombus Formation.

Project description: Not available

| S-EPMC7844783 | biostudies-literature

Outcome of Pediatric Large Vessel Occlusion Stroke in Denmark.

Project description: Not available

| S-EPMC12778532 | biostudies-literature