Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart.

ABSTRACT: Myocardial infarction (MI) is a leading cause of morbidity and mortality around the world. A major goal of regenerative medicine is to replenish the dead myocardium after MI. Although several strategies have been used to regenerate myocardium, stem cell therapy remains a major approach to replenish the dead myocardium of an MI heart. Accumulating evidence suggests the presence of resident cardiac stem cells (CSCs) in the adult heart and their endocrine and/or paracrine effects on cardiac regeneration. However, CSC isolation and their characterization and differentiation toward myocardial cells, especially cardiomyocytes, remains a technical challenge. In the present study, we provided a simple method for the isolation, characterization, and differentiation of CSCs from the adult mouse hear

SUBMITTER: Yadav SK 

PROVIDER: S-EPMC7207148 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature