A survey-wide association study to identify youth-specific correlates of major depressive episodes.

ABSTRACT:

Background

Major depressive disorder is a common disease with high mortality and morbidity worldwide. Though peak onset is during late adolescence, the prevalence of major depressive disorder remains high throughout adulthood. Leveraging an association study design, this study screened a large number of variables in the 2017 National Survey on Drug Use and Health to characterize differences between adult and youth depression across a wide array of phenotypic measurements.

Methods

All dichotomous variables were manually identified from the survey for association screening. Association between each dichotomous variable and past-year major depressive episode (MDE) occurrence was calculated as an odds ratio for adults (≥18 years) and youth (12-17 years), and tested for significa

SUBMITTER: Dhodapkar RM 

PROVIDER: S-EPMC7209284 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature