The double-edged sword role of fibroblasts in the interaction with cancer cells; an agent-based modeling approach.

ABSTRACT: Fibroblasts as key components of tumor microenvironment show different features in the interaction with cancer cells. Although, Normal fibroblasts demonstrate anti-tumor effects, cancer associated fibroblasts are principal participant in tumor growth and invasion. The ambiguity of fibroblasts function can be regarded as two heads of its behavioral spectrum and can be subjected for mathematical modeling to identify their switching behavior. In this research, an agent-based model of mutual interactions between fibroblast and cancer cell was created. The proposed model is based on nonlinear differential equations which describes biochemical reactions of the main factors involved in fibroblasts and cancer cells communication. Also, most of the model parameters are estimated using hybrid unscen

SUBMITTER: Heidary Z 

PROVIDER: S-EPMC7209353 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature