Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment.

ABSTRACT: In solid tumors, increasing drug penetration promotes their regression and improves the therapeutic index of compounds. However, the heterogeneous extracellular matrix (ECM) acts as a steric and interaction barrier that hinders effective transport of therapeutics, including nanomedicines. Specifically, the interactions between the ECM and surface physicochemical properties of nanomedicines (e.g. charge, hydrophobicity) affect their diffusion and penetration. To address the challenges using existing surface chemistries, we used peptide-presenting phage libraries as a high-throughput approach to screen and identify peptides as coatings with desired physicochemical properties that improve diffusive transport through the tumor microenvironment. Through iterative screening against the ECM and i

SUBMITTER: Mohanty RP 

PROVIDER: S-EPMC7209769 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature