Pre-conception 25-hydroxyvitamin D (25(OH)D) and fecundability.

ABSTRACT:

Study question

Is pre-conception 25(OH)D associated with the per cycle probability of conception, i.e fecundability, in a prospective cohort study?

Summary answer

There are suggestive associations of high 25(OH)D (at least 50 ng/ml) with increased fecundability and low 25(OH)D (<20 ng/ml) with reduced fecundability, but the estimates were imprecise.

What is known already

Vitamin D has been associated with reproductive function and fertility in animal studies, but few human studies exist.

Study design, size, duration

This community-based prospective cohort study included 522 women attempting to become pregnant between 2010 and 2016. The women completed online daily and monthly diaries until a positive home pregnancy test was observed or 12 months had elapsed.

SUBMITTER: Jukic AMZ 

PROVIDER: S-EPMC7209776 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature