Coordinated activities of retrosplenial ensembles during resting-state encode spatial landmarks.

ABSTRACT: The brain likely uses offline periods to consolidate recent memories. One hypothesis holds that the hippocampal output provides a unique, global linking or 'index' code for each memory, and that this code is stored in the cortex in association with locally encoded attributes of each memory. Activation of the index code is hypothesized to evoke coordinated memory trace reactivation thus facilitating consolidation. Retrosplenial cortex (RSC) is a major recipient of hippocampal outflow and we have described populations of neurons there with sparse and orthogonal coding characteristics that resemble hippocampal 'place' cells, and whose expression depends on an intact hippocampus. Using two-photon Ca²⁺ imaging, we recorded ensembles of neurons in the RSC during periods of immobility

SUBMITTER: Chang H 

PROVIDER: S-EPMC7209918 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature