The transcription factor ANAC017 is a key regulator of mitochondrial proteotoxic stress responses in plants.

ABSTRACT: Impaired mitochondrial translation or reduced mitochondrial protein import can lead to imbalances in mitochondrial protein composition. Such mitochondrial proteotoxic stresses can trigger a nuclear transcriptional response commonly described as the mitochondrial unfolded protein response (UPR^mt). Despite extensive studies of UPR^mt pathways in animal and fungal systems, very little is known about how the UPR^mt is regulated in plants. Through comparison of Arabidopsis thaliana whole-genome transcriptome data, it was found that most genes induced by mitochondrial ribosome inhibitor doxycycline are also induced by Complex III inhibitor antimycin A. We demonstrate that transcriptional responses to a wide range of mitochondrial proteotoxic stress-triggers

SUBMITTER: Kacprzak SM 

PROVIDER: S-EPMC7209956 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature