A composite likelihood approach in testing for Hardy Weinberg Equilibrium using family-based genetic survey data.

ABSTRACT: In population-based household surveys, for example, the National Health and Nutrition Examination Survey, households are often sampled by stratified multistage cluster sampling, and multiple individuals related by blood are often sampled within households. Therefore, genetic data collected from these population-based household surveys, called National Genetic Household Surveys, can be correlated because of two levels of correlation. One level of correlation is caused by the multistage geographical cluster sampling and the other is caused by biological inheritance among participants within the same sampled family. In this paper, we develop an efficient Hardy Weinberg Equilibrium (HWE) test utilizing pairwise composite likelihood methods that incorporate the sample weighting effect induced b

SUBMITTER: Wang L 

PROVIDER: S-EPMC7210008 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature