Mechanical and finite element evaluation of a bioprinted scaffold following recellularization in a rat subcutaneous model.

ABSTRACT: Tissue engineered heart valves (TEHV) provide several advantages over currently available aortic heart valve replacements. Bioprinting provides a patient-specific means of developing a TEHV scaffold from imaging data, and the capability to embed the patient's own cells within the scaffold. In this work we investigated the remodeling capacity of a collagen-based bio-ink by implanting bioprinted disks in a rat subcutaneous model for 2, 4 and 12 weeks and evaluating the mechanical response using biaxial testing and subsequent finite element (FE) modeling. Samples explanted after 2 and 4 weeks showed inferior mechanical properties compared to native tissues while 12 week explants showed a mechanical response of similar magnitude but did not demonstrate the anisotropy present in native tissues.

SUBMITTER: Noble C 

PROVIDER: S-EPMC7210052 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature