Interfibrillar shear behavior is altered in aging tendon fascicles.

ABSTRACT: Tendon elongation involves both stretching and sliding between adjacent fascicles and fibers. Hence, age-related changes in tendon matrix properties may alter sliding behavior and thereby affect injury thresholds. The objective of this study was to investigate the effects of age on interfibrillar shear behavior in partial cut tendon fascicles. Cine microscopic imaging was used to track deformation patterns of intact and partial cut fascicles from mature (9 months, n = 10) and aged (32 months, n = 10) rat tail tendons. Finite element (FE) models coupled with experimental data provided insight into age-related changes in tissue constitutive properties that could give rise to age-dependent behavior. Intact fascicles from aged tendons exhibited a 28% lower linear region modulus and reduced toe

SUBMITTER: Muench JR 

PROVIDER: S-EPMC7210070 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature