Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage.

ABSTRACT: The cerebellar granule cells (GrCs) are classically described as a homogeneous neuronal population discharging regularly without adaptation. We show that GrCs in fact generate diverse response patterns to current injection and synaptic activation, ranging from adaptation to acceleration of firing. Adaptation was predicted by parameter optimization in detailed computational models based on available knowledge on GrC ionic channels. The models also predicted that acceleration required additional mechanisms. We found that yet unrecognized TRPM4 currents specifically accounted for firing acceleration and that adapting GrCs outperformed accelerating GrCs in transmitting high-frequency mossy fiber (MF) bursts over a background discharge. This implied that GrC subtypes identified by their electro

SUBMITTER: Masoli S 

PROVIDER: S-EPMC7210112 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature