The role of inflammation in a rat model of chronic thromboembolic pulmonary hypertension induced by carrageenan.

ABSTRACT:

Background

Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition arising from the thrombus and obstructive remodeling of the pulmonary arteries, which causes a significant morbidity and mortality. Although the modern treatment in CTEPH has been significant advanced both in surgical and medical treatment, none can claim to cure the disease, largely because of our limited understanding of the underlying pathogenesis of the disease and lack of a reliable CTEPH animal model to study for. Recently, inflammation has been accepted as a common pathway through which various risk factors trigger venous thrombo-embolism (VTE) formation, we describe a novel mouse model of CTEPH which reproduces a frequent trigger and resembles the time course, histological featu

SUBMITTER: Wu D 

PROVIDER: S-EPMC7210127 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature