Nine hub genes related to the prognosis of HBV-positive hepatocellular carcinoma identified by protein interaction analysis.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) represents the second highest cause of cancer-associated deaths worldwide, and hepatitis B virus (HBV) infection is a major risk factor. Here, we aimed to identify genetic signatures of HBV-positive (HBV⁺) HCC and uncover potential carcinogenic mechanisms.

Methods

Gene expression profiles of 124 HBV-positive samples, including tumor and non-tumor tissues were subjected to bioinformatics analysis. The expression levels of thymidylate synthase (TYMS) and CDC45 in patients' samples were validated by immunohistochemistry (IHC) and their association with patient survival was assessed by the Kaplan-Meier method.

Results

A total of 666 differentially expressed genes (DEGs) were identified. The 137 upregulated genes were ma

SUBMITTER: Xie W 

PROVIDER: S-EPMC7210132 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature