Aspirin use and endometrial cancer risk: a meta-analysis and systematic review.

ABSTRACT:

Background

The use of aspirin has been linked to a reduced risk of cancer at several sites, such as the breast, prostate, and colorectum. However, the evidence for this chemopreventive effect from aspirin use on endometrial cancer is conflicting, and whether an association exists is an open question.

Methods

After carrying out a database search of articles published up to December 2019, we identified 7 case-control studies and 11 cohort studies, including a total of 14,766 endometrial cancer cases. We pooled the odds ratios (ORs) in case-control studies and risk ratios (RRs) in cohort studies, and then conducted subgroup analysis based on factors such as the frequency and duration of aspirin use, and obesity.

Results

In the overall meta-analysis, we found a significan

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7210134 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature