High RPS11 level in hepatocellular carcinoma associates with poor prognosis after curative resection.

ABSTRACT:

Background

Ribosomal protein S11 (RPS11), a member of ribosomal protein family, is reported to overexpress in diverse malignancies and correlates with tumor recurrence. However, our current knowledge on RPS11 in hepatocellular carcinoma (HCC) remains limited. In this study, we are going to explore the potential prognostic value of RPS11 in HCC patients after curative resection.

Methods

Immunohistochemistry (IHC) was performed to evaluate RPS11 expression on tissue microarrays in training cohort comprising 182 HCC patients and validation cohort enrolling 90 HCC patients in Zhongshan Hospital, Fudan University. Western blot and quantitative reverse transcription PCR (qRT-PCR) were also used to determine the expression level of RPS11 in liver cell lines. Two nomograms, calibrat

SUBMITTER: Zhou C 

PROVIDER: S-EPMC7210141 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature