MicroRNA-34a deficiency leads to impaired wound closure by augmented inflammation in mice.

ABSTRACT:

Background

Proper inflammation resolution is critical for cutaneous wound healing and disordered inflammation resolution results in chronic nonhealing wounds. However, the cellular and molecular mechanisms for resolution of inflammation during skin wound healing are not well understood. MicroRNA-34a is regarded as one tumor suppressor with complexed immune regulatory effects, yet its role during skin wound repair is still unclear.

Methods

Circular full thickness excisional wounds were made on the dorsal skin of C57 mice and miR-34a expression pattern was examined by real time RT-PCR and in situ hybridization. The wound healing rates and histologic morphometric analysis were quantified and compared between wounds treated with antagomir-34a and autologous control antago

SUBMITTER: Zhao N 

PROVIDER: S-EPMC7210195 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature