The effect of RAS blockers on the clinical characteristics of COVID-19 patients with hypertension.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus (designated as SARS-CoV-2) has become a pandemic worldwide. Based on the current reports, hypertension may be associated with increased risk of sever condition in hospitalized COVID-19 patients. Angiotensin-converting enzyme 2 (ACE2) was recently identified to functional receptor of SARS-CoV-2. Previous experimental data revealed ACE2 level was increased following treatment with ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). Currently doctors concern whether these commonly used renin-angiotensin system (RAS) blockers-ACEIs/ARBs may increase the severity of COVID-19.

Methods

We extracted data regarding 50 hospitalized hypertension patients with laboratory confirmed COVID-19 in the

SUBMITTER: Huang Z 

PROVIDER: S-EPMC7210199 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature