IntegrinB5 upregulated by HER2 in gastric cancer: a promising biomarker for liver metastasis.

ABSTRACT:

Background

Liver is the most frequent metastatic site of gastric cancer (GC), especially in patients with HER2 positive GC. Exosomal integrin αvβ5 has been shown to promote liver metastasis (LM), and the cross talk between integrins and HER2 during breast cancer metastasis has been reported. However, whether there's an association between HER2 and integrin αvβ5 (ITGAvB5), and whether their association has predictive value in GC liver metastasis (GCLM) remains unknown.

Methods

The association between ITGβ5 and HER2 were accessed by RT-PCR, western blot and ELISA. We tested the function of ITGβ5 on HER2 positive GC cells using Transwell assays and scratch assays. Besides, we detect ITGβ5 expression in tumor tissue of GC patients and exosomes derived from advanced GC to analyze

SUBMITTER: Li Q 

PROVIDER: S-EPMC7210205 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature