Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study.

ABSTRACT:

Purpose

The aim of the RUBY study was to evaluate novel candidate biomarkers to enable prediction of persistence of renal dysfunction as well as further understand potential mechanisms of kidney tissue damage and repair in acute kidney injury (AKI).

Methods

The RUBY study was a multi-center international prospective observational study to identify biomarkers of the persistence of stage 3 AKI as defined by the KDIGO criteria. Patients in the intensive care unit (ICU) with moderate or severe AKI (KDIGO stage 2 or 3) were enrolled. Patients were to be enrolled within 36 h of meeting KDIGO stage 2 criteria. The primary study endpoint was the development of persistent severe AKI (KDIGO stage 3) lasting for 72 h or more (NCT01868724).

Results

364 patients were enrolled of w

SUBMITTER: Hoste E 

PROVIDER: S-EPMC7210248 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature