Epidemiologic Characteristics of Acute Kidney Injury During Cisplatin Infusions in Children Treated for Cancer.

ABSTRACT:

Importance

Few multicenter pediatric studies have comprehensively described the epidemiologic characteristics of cisplatin-associated acute kidney injury using standardized definitions.

Objective

To examine the rate of and risk factors associated with acute kidney injury among children receiving cisplatin infusions.

Design, setting, and participants

This prospective cohort study examined children (aged <18 years) recruited from May 23, 2013, to March 31, 2017, at 12 Canadian pediatric academic health centers who were receiving 1 or more cisplatin infusion. Children whose estimated or measured glomerular filtration rate (GFR) was less than 30 mL/min/1.73 m2 or who had received a kidney transplant were excluded. Data analysis was performed from January 3, 2018, to Septe

SUBMITTER: McMahon KR 

PROVIDER: S-EPMC7210480 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature