Isocitrate dehydrogenase 2 deficiency aggravates prolonged high-fat diet intake-induced hypertension.

ABSTRACT: The development of hypertension is associated with mitochondrial redox balance disruptions. NADP⁺-dependent isocitrate dehydrogenase 2 (IDH2) plays an important role in the maintenance of mitochondrial redox balance by producing mitochondrial NADPH, which is an essential cofactor in the reduction of glutathione (from GSSG to GSH) to reduced form of glutathione (GSH). We investigated the association of IDH2 between the development of prolonged high-fat diet (HFD)-induced hypertension. Idh2 gene-deleted (Idh2^-/-) male mice and wild-type (Idh2^+/+) littermates were fed either HFD or low-fat diet (LFD). Some mice were administrated with Mito-TEMPO, a mitochondria-specific antioxidant. HFD feeding increased blood pressure (BP) in both Idh2^-/- mice and

SUBMITTER: Noh MR 

PROVIDER: S-EPMC7210593 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature