Histologic Case Definition of an Atypical Glomerular Immune-Complex Deposition Following Kidney Transplantation.

ABSTRACT:

Introduction

Immune-complex deposition in the transplanted kidney can present as well-phenotyped recurrent or de novo glomerular disease. However, a subset, herein termed immune-complex glomerulopathy not otherwise specified (ICG-NOS), defies classification. We quantified, categorized, and characterized cases of transplant ICG-NOS occurring at a single US academic medical center.

Methods

We retrospectively reviewed our single-institution pathology database (July 2007-July 2018) to identify and categorize all cases of immune-complex deposition in kidney allografts (based on immunofluorescence microscopy). We extracted clinicopathologic and outcome data for ICG-NOS (i.e., immune complex deposition not conforming to any well-characterized glomerular disease entity).

Results<

SUBMITTER: Chin KK 

PROVIDER: S-EPMC7210607 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature