Serum lipids profiling perturbances in patients with ischemic heart disease and ischemic cardiomyopathy.

ABSTRACT:

Background

Ischemic heart disease (IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in these patients.

Methods

In this cross-sectional study, we analyzed serum lipids profile in IHD and ICM patients using a lipidomics approach. Consecutive consenting patients admitted to the hospital for IHD and ICM were enrolled. Serum samples were obtained after overnight fasting. Non-targeted metabolomics was applied to demonstrate lipids metabolic profile in control, IHD and ICM patients.

Results

A total of 63 and 62 lipids were detected in negative and positive ion mode

SUBMITTER: Yang L 

PROVIDER: S-EPMC7210665 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature