Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.

ABSTRACT:

Background

The contributions of brain intercellular communication mechanisms, specifically extracellular vesicles (EV), to the progression of Alzheimer's disease (AD) remain poorly understood.

Methods

Here, we investigated the role(s) of brain EV in the progressive course of AD through unbiased proteome-wide analyses of temporal lobe-derived EV and proteome-label quantitation of complementary remaining brain portions. Furthermore, relevant proteins identified were further screened by multiple reaction monitoring.

Results

Our data indicate that EV biogenesis was altered during preclinical AD with the genesis of a specific population of EV containing MHC class-type markers. The significant presence of the prion protein PrP was also manifested in these brain vesicles dur

SUBMITTER: Gallart-Palau X 

PROVIDER: S-EPMC7210691 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature