Spatial models of cell distribution in human lumbar dorsal root ganglia.

ABSTRACT: Dorsal root ganglia (DRG), which contain the somata of primary sensory neurons, have increasingly been considered as novel targets for clinical neural interfaces, both for neuroprosthetic and pain applications. Effective use of either neural recording or stimulation technologies requires an appropriate spatial position relative to the target neural element, whether axon or cell body. However, the internal three-dimensional spatial organization of human DRG neural fibers and somata has not been quantitatively described. In this study, we analyzed 202 cross-sectional images across the length of 31 human L4 and L5 DRG from 10 donors. We used a custom semi-automated graphical user interface to identify the locations of neural elements in the images and normalize the output to a consistent spat

SUBMITTER: Sperry ZJ 

PROVIDER: S-EPMC7211131 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature