Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure.

ABSTRACT:

Background

While translational theories link neurodevelopmental changes in threat learning to pathological anxiety, findings from studies in patients inconsistently support these theories. This inconsistency may reflect difficulties in studying large patient samples with wide age ranges using consistent methods. A dearth of imaging data in patients further limits translational advances. We address these gaps through a psychophysiology and structural brain imaging study in a large sample of patients across the lifespan.

Methods

A total of 351 participants (8-50 years of age; 209 female subjects; 195 healthy participants and 156 medication-free, treatment-seeking patients with anxiety) completed a differential threat conditioning and extinction paradigm that has been validated

SUBMITTER: Abend R 

PROVIDER: S-EPMC7211142 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature