Diagnostic, progressive and prognostic performance of m⁶A methylation RNA regulators in lung adenocarcinoma.

ABSTRACT: Background: N6-methyladenosine (m⁶A) RNA methylation is dynamically and reversibly regulated by methyl-transferases ("writers"), binding proteins ("readers"), and demethylases ("erasers"). The m⁶A is restored to adenosine and thus to achieve demethylation modification. The abnormality of m⁶A epigenetic modification in cancer has been increasingly attended. However, we are rarely aware of its diagnostic, progressive and prognostic performance in lung adenocarcinoma (LUAD). Methods and Results: The expression of 13 widely reported m⁶A RNA regulators in LUAD and normal samples were systematically analyzed. There were 12 m⁶A RNA methylation genes displaying aberrant expressions, and an 11-gene diagnostic score model was final

SUBMITTER: Zhuang Z 

PROVIDER: S-EPMC7211177 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature