Ontology highlight
ABSTRACT:
SUBMITTER: Zhao YQ
PROVIDER: S-EPMC7211185 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Biometrics 20191107 2
Traditionally, a clinical trial is conducted comparing treatment to standard care for all patients. However, it could be inefficient given patients' heterogeneous responses to treatments, and rapid advances in the molecular understanding of diseases have made biomarker-based clinical trials increasingly popular. We propose a new targeted clinical trial design, termed as Max-Impact design, which selects the appropriate subpopulation for a clinical trial and aims to optimize population impact once ...[more]