Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity.

ABSTRACT:

Background

Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the metabolic mechanism underlying this correlation is not understood.

Objective

Our objective was to examine metabolomic links between SSB intake and obesity to understand metabolic mechanisms.

Design

We examined the association of plasma metabolomic profiles with SSB intake and obesity risk in 781 participants, aged 45-75 y, in the Boston Puerto Rican Health Study (BPRHS) using generalized linear models, controlling for potential confounding factors. Based on identified metabolites, we conducted pathway enrichment analysis to identify potential metabolic pathways that link SSB intake and obesity risk. Variants in genes encoding enzymes known to function in identified metabol

SUBMITTER: Zhou B 

PROVIDER: S-EPMC7211252 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature